Is one of the enhanced vaccines (FLUZONE® High-Dose Quadrivalent and FLUAD®) recommended over the other for adults 65 years of age and older?

Question: 
Is one of the enhanced vaccines (FLUZONE® High-Dose Quadrivalent and FLUAD®) recommended over the other for adults 65 years of age and older? 
 
Answer: 
No. There is not enough evidence to show that one of these enhanced vaccines is better than the other.  Either of the enhanced vaccines (FLUZONE® High-Dose Quadrivalent and FLUAD®) are recommended for adults 65 years of age and older.  
 
Randomized control trials and observational studies have shown that both enhanced influenza vaccines are better than standard-dose unadjuvanted influenza vaccines when it comes to preventing influenza-related hospitalization in adults 65 years of age and older.
 
Date last reviewed: 
Tuesday, Aug 23, 2022