Will immunity to adenoviruses (that cause the common cold in humans) interfere with my immune response to the COVID-19 vaccines? (since some vaccines are using the adenoviruses to deliver the genetic material to the immune cells).

Question: 

Will immunity to adenoviruses (that cause the common cold in humans) interfere with my immune response to the COVID-19 vaccines?  (since some vaccines are using the adenoviruses to deliver the genetic material to the immune cells).

Answer: 

Yes, you can potentially develop an immune response to the different strains of adenoviruses that are being used in some of the COVID-19 vaccines. Because of this, scientists are watching closely to measure the real-life effectiveness of the vaccines. Furthermore, certain companies using these types of viral vectors are choosing different strains of adenoviruses within the same vaccine series. For example, the Russian “Sputnik” vaccine uses both Adenovirus26 and Adenovirus5 in the two dose series. This is intended to overcome any pre-existing immunity to these viruses in the population.

Date last reviewed: 
Wednesday, Mar 24, 2021